NuAge Database and Biobank
NuAge is a unique cohort of elderly subjects, distinctive by the quality, diversity and complementarity of the data and biological samples made available to the scientific community to conduct multiple secondary research projects. This cohort took form between November 2003 and June 2008 as part of the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge Study), funded by the Canadian Institutes of Health Research (CIHR; $3.8M) and supported for more than 10 years by the Réseau québécois de recherche sur le vieillissement (RQRV) [Quebec Network for Research on Aging]. In brief, 1,793 healthy men and women between 67 and 84 years of age, living in the regions of Montreal, Laval and Sherbrooke (Province of Quebec, Canada), were recruited in the NuAge cohort. More than 1,000 variables were collected annually for 4 years, totaling 3 years of follow-up. These variables include data about lifestyle habits, socioeconomic status, social participation, overall health, body composition, physical capabilities, functional autonomy, cognitive and mental health, medication, and use of supplements and natural products. The annual collection of fasting blood (serum, plasma, peripheral blood mononuclear cells), urine and saliva samples, currently stored in a computerized biobank, complement these data.
In 2018-2019, a major project was completed to define a new management framework and proceed with the migration of the data and biological samples of 1,753 of the 1,793 (98%) participants of the NuAge cohort into a research bank officially registered under the name " NuAge Database and Biobank ". This status ensures that the infrastructure complies with the ethical and legislative requirements effective in Quebec regarding research banks.
The mission of the NuAge Database and Biobank is to maintain, enrich and promote an infrastructure that allows sharing of high quality data and biological samples with the scientific community as part of research projects aiming to characterize the heterogeneity of aging trajectories and the multiple underlying factors, in order to improve the overall health and quality of life of the elderly.
From 2003 to March 2021, the NuAge milestones include nearly :
- 86 scientific articles cited more than 3,100 times (h index = 32; Google Scholar)
- 320 presentations (oral, posters, invited) as part of scientific meetings
- 30 media communications about the NuAge cohort
- 113 graduate students, interns and fellows who used NuAge data or biological samples as part of their studies
- $6.3M in grants (research, operation) for the NuAge Study and NuAge Database and Biobank
- 23 secondary research projects accepted or in progress
- 59 secondary research projects completed
- 11 research partners and consortia, including 3 at the international level